The New Jersey Institute of Technology's
Electronic Theses & Dissertations Project

Title:	Mathematical modeling of transient state transdermal drug delivery
Author:	Weltner, Alison Nickol
View Online:	njit-etd2004-076 (x, 83 pages ~ 3.9 MB pdf)
Department:	Department of Chemical Engineering
Degree:	Master of Science
Program:	Pharmaceutical Engineering
Document Type:	Thesis
Advisory Committee:	Simon, Laurent (Committee chair) Armenante, Piero M. (Committee member) Michniak, Bozena B. (Committee member)
Date:	2004-05
Keywords:	Transdermal drug delivery Iontophoresis
Availability:	Unrestricted
Abstract:	In this work, a two-pathway mathematical model for transdermal drug delivery with iontophoresis is presented. The partial differential equations are described and then solved. An alternative, two-pathway, three-layer model is also presented, and the implications of the coefficients within the equation are discussed. Using Franz cell iontophoretic delivery data from three drug substances (amitriptyline HCl, clomipramine HCl, and nortriptyline HCl), the two-pathway model is regressed to determine the diffusion coefficient and the concentration within the skin at the drug reservoir interface. ANOVA analysis indicates a correlation between iontophoretic current and concentration of drug within the stratum corneum.