The New Jersey Institute of Technology's
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Title:	Angiogenic supports for microvascular engineering
Author:	Siddiqui, Zain
View Online:	njit-etd2022-076 (xviii, 139 pages ~ 20.8 MB pdf)
Department:	Department of Biomedical Engineering
Degree:	Doctor of Philosophy
Program:	Biomedical Engineering
Document Type:	Dissertation
Advisory Committee:	Kumar, Vivek A. (Committee chair) Lee, Eun Jung (Committee member) Grasman, Jonathan M. (Committee member) Shimizu, Emi (Committee member) Del Re, Dominic (Committee member)
Date:	2022-12
Keywords:	Acellular scaffolds Angiogenesis Biomaterials Peptide hydrogel Self-assembly Tissue regeneration
Availability:	Unrestricted
Abstract:	Ischemic tissue disease is caused by a lack of circulation / blood supply to tissue. This can be treated by introducing a number of angiogenic (pro-blood vessel forming) factors into the tissue. This work presents strategies for ischemic tissue treatment utilizing a novel proangiogenic self-assembling peptide hydrogel platform. To demonstrate the utility of this platform, its use alone as an angiogenic therapeutic (both alone as a self-assembling hydrogel and with two-component systems), and its ability to vascularize implants is explored. Due to these angiogenic scaffolds demonstrating efficacy to regenerate microvasculature, this work evaluates diseases that can be treated by the regeneration of microvasculature - such as the soft tissue in the dental pulp and ocular microvessel healing.