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Title:	Itraconazole nanocomposites prepared via rotary evaporator drying of nanomilled suspensions
Author:	Coelho, Alexander Santos
View Online:	njit-etd2021-058 (xiv, 66 pages ~ 15.0 MB pdf)
Department:	Department of Chemical and Materials Engineering
Degree:	Master of Science
Program:	Chemical Engineering
Document Type:	Thesis
Advisory Committee:	Bilgili, Ecevit Atalay (Committee chair) McEnnis, Kathleen (Committee member) Voronov, Roman S. (Committee member)
Date:	2021-12
Keywords:	Dissolution enhancement Drug nanoparticles Polymers Redispersibility Rotary evaporation
Availability:	Unrestricted
Abstract:	The aim of this study is to explore the feasibility of rotary evaporation for drying wetmilled drug suspensions as a novel approach to produce drug nanocomposites that exhibit fast redispersion and immediate drug release. To this end, the physical stability of the nanomilled itraconazole (drug) suspensions, a.k.a., nanosuspensions, during the milling and storage; the drying of the itraconazole nanosuspensions via the rotary evaporator; and the type/loading of various polymers/surfactants (dispersants) on aqueous redispersion and drug release from the nanocomposites were examined. Our results suggest that smaller drug particle size, owing to nanomilling, and smaller nanocomposite particle size, owing to optimized drying and subsequent mortar-pestle milling, as well as higher concentration of hydrophilic polymers/surfactants enhanced redispersion and drug release. Overall, rotary evaporation of drug nanosuspensions could achieve fast redispersion and immediate release of poorly soluble drugs from these nanocomposites, with less concern over potential flowability issues than spray-dried nanocomposites.