The New Jersey Institute of Technology's
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Title:	The role of irak-1 transcripts in sepsis
Author:	Subramanian Sahasranamam, Adithya
View Online:	njit-etd2021-031 (xi, 92 pages ~ 2.8 MB pdf)
Department:	Federated Biological Sciences Department of NJIT and Rutgers-Newark
Degree:	Master of Science
Program:	Biology
Document Type:	Thesis
Advisory Committee:	Gao, Nan (Committee chair) Morcillo, Patrick (Committee member) Bucher, Dirk (Committee member)
Date:	2021-05
Keywords:	Sepsis Interleukin-1 receptor-associated kinase pathways Molecular mechanisms
Availability:	Unrestricted
Abstract:	Sepsis is a complex, life-threatening syndrome that can lead to systemic organ failure and dysfunction. Its high morbidity and mortality rates makes it a critical global health issue. The primary factors at play during sepsis are abnormal inflammation and a lack of oxygen supply to the tissues and muscles. The toll-like receptors play a crucial role in eliciting innate immune in response to infection, primarily through the interleukin-1 receptor-associated kinase (IRAK) pathways. Disturbances in the homeostasis of IRAK signaling cascades can lead to immune dysfunction. n this paper, we review the molecular mechanisms of IRAK-1, an important mediator of TLR-induced inflammation and compare the effects of its splice variants and polymorphisms in the context of inflammation and sepsis.