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Title:	Transdermal and transbuccal delivery of lidocaine and nicotine : combined effects of iontophoresis and chemical enhancers
Author:	Wei, Ran
View Online:	njit-etd2011-084 (x, 32 pages ~ 0.4 MB pdf)
Department:	Department of Chemical, Biological and Pharmaceutical Engineering
Degree:	Master of Science
Program:	Pharmaceutical Engineering
Document Type:	Thesis
Advisory Committee:	Simon, Laurent (Committee chair) Armenante, Piero M. (Committee member) Loney, Norman W. (Committee member) Michniak, Bozena B. (Committee member)
Date:	2011-05
Keywords:	Iontophoresis Enhancer Transdermal Transbuccal
Availability:	Unrestricted
Abstract:	This study focused on the effects of iontophoresis and chemical enhancers on drug release. The transport of Lidocaine HCl (LHCl) and Nicotine Hydrogen Tartrate (NHT) through the skin and mucosa was evaluated for potential clinical applications. These two potential delivery routes have the advantage of avoiding first-pass effect. Samples were pretreated with enhancer solutions for one hour before the experiments. Passive or 0.3 mA iontophoresis-assisted drug diffusion was conducted for 8 hours to monitor the cumulative amount of drug released. Graphical methods and mathematical optimization techniques were implemented to analyze the data. The effects of chemical enhancers on the delivery rate depend largely on the drug used while iontophoresis mainly increases the steady-state flux. Parametric analyses show that a balance between high flux and fast release should be considered when conducting formulation and optimization studies.