The New Jersey Institute of Technology's
Electronic Theses & Dissertations Project

Title:	Type-1 diabetes risk prediction using multiple kernel learning
Author:	Garg, Paras
View Online:	njit-etd2010-054 (xi, 20 pages ~ 1.4 MB pdf)
Department:	Department of Computer Science
Degree:	Master of Science
Program:	Bioinformatics
Document Type:	Thesis
Advisory Committee:	Roshan, Usman W. (Committee chair) Wang, Jason T. L. (Committee member) Wei, Zhi (Committee member)
Date:	2010-05
Keywords:	Diabetes risk prediction Multiple kernal learning
Availability:	Unrestricted
Abstract:	This thesis presents an analysis of multiple kernel learning (MKL) for type-1 diabetes risk prediction. MKL combines different models and representation of data to find a linear combination of these representations of the data. MKL has been successfully been implemented in image detection, splice site detection, ribosomal and membrane protein prediction, etc. In this thesis, this method was applied for Genome-wide association study (GWAS) for classifying cases and controls. This thesis has shown that combined kernel does not perform better than the individual kernels and that MKL does not select the best model for this problem. Also, the effect of normalization on MKL as well as risk prediction has also been analyzed.