Articles via Databases
Articles via Journals
Online Catalog
E-books
Research & Information Literacy
Interlibrary loan
Theses & Dissertations
Collections
Policies
Services
About / Contact Us
Administration
Littman Architecture Library
This site will be removed in January 2019, please change your bookmarks.
This page will redirect to https://digitalcommons.njit.edu/theses/569 in 5 seconds

The New Jersey Institute of Technology's
Electronic Theses & Dissertations Project

Title: Biomimetic sensor for in-vivo applications
Author: Sooryadas, Daya I.
View Online: njit-etd2004-071
(x, 79 pages ~ 4.4 MB pdf)
Department: Department of Biomedical Engineering
Degree: Master of Science
Program: Biomedical Engineering
Document Type: Thesis
Advisory Committee: Jaffe, Michael (Committee co-chair)
Cubicciotti, Roger (Committee co-chair)
Kristol, David S. (Committee member)
Soteropoulos, Patricia (Committee member)
Date: 2004-05
Keywords: Molecular sensors
Pollutants
Biological agents
Availability: Unrestricted
Abstract:

The development of sensitive specific devices (e.g., molecular sensors) for the detection, diagnosis and monitoring of diseases, drug discovery, environmental detection of pollutants and/or biological agents has been an active area of research. A molecular sensor is a biomolecule or biomimetic molecule that performs two distinct functions in detecting target molecules. The sensor molecule recognizes a target molecule and specifically binds to it. This specific binding generates a signal in response to the event of target binding that can be then detected. The long term vision of this thesis research work is to develop a specific recognition ligand for detecting proteins in living cell. A molecular sensor for non-nucleic acid analytes (e.g., proteins, peptides, drugs, hormones) can be designed and demonstrated using molecular recognition and design principles analogous in some ways to the molecular switch principles used in Molecular Beacons invented by Dr. Kramer and Dr. Tyagi.

Conventionally, people have looked at nucleic acids and antibodies used as nucleic acid recognizing nucleic acid and antigen recognizing antibody. Nucleic acids have protein binding capabilities i.e. they can act as aptamers having same design construct as molecular beacons. Aptamer nucleic acids act as antibodies which can detect antigens. This thesis work focuses on the development of some basic tools and concepts for the development of aptamer beacons, like immobilization of molecules on substrates and to determine the performance of specific binding assays.


If you have any questions please contact the ETD Team, libetd@njit.edu.

 
ETD Information
Digital Commons @ NJIT
Theses and DIssertations
ETD Policies & Procedures
ETD FAQ's
ETD home

Request a Scan
NDLTD

NJIT's ETD project was given an ACRL/NJ Technology Innovation Honorable Mention Award in spring 2003