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The New Jersey Institute of Technology's
Electronic Theses & Dissertations Project

Title: Renin-angiotensin system and its relationship to arterial pressure regulation
Author: Saume, Sami D.
View Online: njit-etd1997-088
(ix, 62 pages ~ 1.8 MB pdf)
Department: Biomedical Engineering Committee
Degree: Master of Science
Program: Biomedical Engineering
Document Type: Thesis
Advisory Committee: Ritter, Arthur B. (Committee chair)
Lacker, H. Michael (Committee member)
Kristol, David S. (Committee member)
Date: 1997-05
Keywords: Kidney function--Mathematical models.
Blood pressure--Regulation.
Availability: Unrestricted
Abstract:

The renal system is known to participate in the natural regulation of blood pressure. A renal system model that simulates interaction responses of renal output to arterial blood pressure was developed. The major components of this model are glomerular filtration rate, tubular sodium reabsorption, the renin-angiotensin system, Aldosterone secretion, and antidiuretic hormone secretion. The model's differential equations were coded using Vissim 1.2 student version. It was found that, the renal output increased as glomerular filtration rate, Aldosterone concentration, and blood pressure increased. Conversely, increasing antidiuretic hormone concentration lead to decreased renal output.

Additionally, Angiotensin II and Aldosterone concentrations increased as the arterial pressure decreased. The model suggests that increasing renal output leads to decreased blood volume, which aids in the long term regulation of blood pressure.


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