Articles via Databases
Articles via Journals
Online Catalog
E-books
Research & Information Literacy
Interlibrary loan
Theses & Dissertations
Collections
Policies
Services
About / Contact Us
Administration
Littman Architecture Library
This site will be removed in January 2019, please change your bookmarks.
This page will redirect to https://digitalcommons.njit.edu/theses/1012 in 5 seconds

The New Jersey Institute of Technology's
Electronic Theses & Dissertations Project

Title: Oxidized sterols in patients with diabetic heart disease and microwave-mediated stereoselective synthesis of 3-keto cholesterol and cholesterol epoxide, cholesteryl ester epoxides
Author: Kothavale, Meenakashi N.
View Online: njit-etd1997-063
(ix, 33 pages ~ 1.2 MB pdf)
Department: Department of Chemical Engineering, Chemistry and Environmental Science
Degree: Master of Science
Program: Applied Chemistry
Document Type: Thesis
Advisory Committee: Kristol, David S. (Committee co-chair)
Dayal, Bishambar (Committee co-chair)
Barash, Louis (Committee member)
Date: 1997-01
Keywords: Atherosclerotic plaque.
Cholesterol oxides.
Availability: Unrestricted
Abstract:

Oxidized low density lipoproteins (ox-LDL) may play important role in mediating hypercholesterolemic endothelial dysfunction. The uptake of modified LDL by macrophages to form foam cells has been implicated in the enhancement of atherosclerosis. Recent reports have suggested that when LDL undergoes oxidation in vitro , it is accompanied by a substantial loss of free and esterified cholesterol leading to the formation of oxidation products of cholesterol ( oxysterols). These compounds are present in human atherosclerotic plaques and in human foam cells.

In this regard we have recently studied the plasma sterol composition in diabetic heart patients We have found cholesterol a- and β-epoxides in addition to 7-ketocholesterol and 7a- and β-hydroxycholesterol. In order to characterize the structure and stereochemistry of cholesterol epoxides in diabetic patients, they were chemically synthesized via a rapid and convenient microwave irradiation technique. The structures of these compounds were determined by NMR and a combination of TLC-fast atom bombardment mass spectrometry. FAB-MS for Oxysterols: 5,6-epoxycholesterol, [M+= 402, (M+H+Na)+= 425, (2M+H+Na)+= 827]; 5,6-epoxy cholesteryl palmitate (M+Na)+= 663; 5,6-epoxy 3-ketocholesterol (M+H)+= 401.


If you have any questions please contact the ETD Team, libetd@njit.edu.

 
ETD Information
Digital Commons @ NJIT
Theses and DIssertations
ETD Policies & Procedures
ETD FAQ's
ETD home

Request a Scan
NDLTD

NJIT's ETD project was given an ACRL/NJ Technology Innovation Honorable Mention Award in spring 2003