The New Jersey Institute of Technology's
Electronic Theses & Dissertations Project

Title:	The application of stereolithography to the creation of molecular models of amiloride and its analogues
Author:	Busanic, Thomas John
View Online:	njit-etd1994-066 (x, 40 pages ~ 1.5 MB pdf)
Department:	Department of Chemical Engineering, Chemistry and Environmental Science
Degree:	Master of Science
Program:	Applied Chemistry
Document Type:	Thesis
Advisory Committee:	Venanzi, Carol A. (Committee chair) Gund, Tamara M. (Committee member) Grow, James M. (Committee member)
Date:	1994-05
Keywords:	Amiloride--Structure. CAD/CAM systems. Lithography. Laser beam lithography.
Availability:	Unrestricted
Abstract:	Stereolithography, a process by which a computer-guided Ultraviolet (UV) laser is applied onto a liquid monomer resin to form a solid polymer, was used to create solid models of amiloride and two of its analogues. The Cartesian coordinates used as input for the orientation of each atom in a molecule were calculated using ab initio molecular orbital theory. Since the structures of the molecules are calculated in this fashion, they represent a more accurate representation of the molecules than that provided by standard molecular modeling kits. The original purpose of this work was to assist a blind chemist in appreciating the structure of amiloride and two of its analogues. The models not only serve blind individuals, but also serve as a communication link between blind and sighted individuals. The models also have the potential to be used as learning aides to blind and sighted students at the high school and college level.