The New Jersey Institute of Technology's
Electronic Theses & Dissertations Project

Title:	A multicompartmental model for the simulation of soluble gas exchange in the lungs
Author:	Varadhan, Chitaranjan
View Online:	njit-etd1993-155 (viii, 50 pages ~ 1.3 MB pdf)
Department:	Biomedical Engineering Committee
Degree:	Master of Science
Program:	Biomedical Engineering
Document Type:	Thesis
Advisory Committee:	Ritter, Arthur B. (Committee chair) Kristol, David S. (Committee member) Parker, Richard Clyde (Committee member)
Date:	1993-05
Keywords:	Gases -- Absorption and adsorption -- Models Lung -- Blood vessels -- Models Anesthesia
Availability:	Unrestricted
Abstract:	A dynamic multicompartmental model for respiratory exchange of soluble gas is described. The motivation for this new model is the continuing interest in estimating pulmonary system parameters during anesthesia and under diseased conditions. Here a four compartment model for the blood-tissue gas exchange is described, which will be coupled to a whole body hemodynamic model developed earlier. With this pulmonary model we can simulate the pharmacokinetics of inhaled anesthetic agents at any instant of time. Simulations are computed using the TUTSIM software package. Values for the physiological parameters used in the simulation are estimated from standard physiological sources. Where necessary, parameter values reported for animal studies were adjusted to reflect normal human physiology.