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Title:	Optimization of flow in the collecting duct during the concentrating mode and the diluting mode in a nephron population of two different length with the renin angiotensin system and ADH mechanism
Author:	Subramanian, Sivakumar
View Online:	njit-etd1993-146 (x, 55 pages ~ 1.9 MB pdf)
Department:	Biomedical Engineering Committee
Degree:	Master of Science
Program:	Biomedical Engineering
Document Type:	Thesis
Advisory Committee:	Lacker, H. Michael (Committee chair) Laxminarayan, Swamy (Committee member) Kristol, David S. (Committee member)
Date:	1993-10
Keywords:	Renal tubular transport -- Mathematical models. Kidney tubules.
Availability:	Unrestricted
Abstract:	Our present study is to find out how the short and long nephrons are interacting in the human kidney to adjust the flow in the collecting duct to have the maximum flow during the diluting mode and minimum flow during the concentrating mode. The best lengths for the short nephron and long nephron are calculated during the concentrating mode and the diluting mode by using the Newton-Raphson method. If one wants the kidney to perform only the above mentioned functions, a design criteria for an artificial kidney has been proposed. These studies have provided qualitative information regarding the concentrating mechanism and illustrates well the problem involved in attempting to describe accurately the function of an organ like kidney.