The New Jersey Institute of Technology's
Electronic Theses & Dissertations Project

Title:	Mathematical model and simulation of the progression of cutaneous T-cell lymphoma
Author:	Agostinho, Maria L.
View Online:	njit-etd1992-021 (vii, 55 pages ~ 2.7 MB pdf)
Department:	Biomedical Engineering Committee
Degree:	Master of Science
Program:	Biomedical Engineering
Document Type:	Thesis
Advisory Committee:	Sofer, Samir S. (Committee chair) Kristol, David S. (Committee member) Ritter, Arthur B. (Committee member)
Date:	1992-10
Keywords:	T cells. Lymphomas--Growth--Mathematical models.
Availability:	Unrestricted
Abstract:	A simple mathematical model and simulation of the progression of cancer with particular emphasis on Cutaneous T Cell Lymphoma was investigated. The mathematical model consists of a set of differential equations that first satisfies the homeostasis levels of the different components present and second predicts the dynamics during a diseased or unhealthy condition. The simulation was done using a FORTRAN program for integrating the differential equations. Simulation of the immune system is important in evaluating the usefulness of particular sorts of biologically targeted therapies and in selecting the most promising treatment strategies for clinical trials. In particular, the effects of leukapheresis and photopheresis in the treatment of CTCL was investigated using the model and available data. Simulation is also important for testing the effectiveness of new drugs on the system.